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2009, discovery of a brand new phenotype for germs in slim nanofluidic slits; and 1st detection of community protein buildings alongside DNA working with solid-point out nanoporesHuman Rad51 filaments on double- and one-stranded DNA: correlating normal and irregular varieties with recombination function.
Dynamics of initiation, termination and reinitiation of DNA translocation through the motor protein EcoR124I
Since 2000, Dekker has shifted the principle aim of his function in direction of biophysics where by he research the Homes of one biomolecules and cells utilizing the equipment of nanotechnology. This alteration of field was driven by his fascination to the amazing performing of biological molecular structures, along with with the very long-time period perspective that a lot of intriguing discoveries is often predicted During this field.[5] Present traces of research in his biophysics group are in the areas of:[6]
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Case in point (three) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in gray, the rim in the pore is highlighted in red, in addition to a 3D rendering on the motion of your DNA rod is shown.
Because 2000 he moved to one-molecule biophysics and nanobiology, with exploration from DNA supercoiling reports of nucleosomes and DNA fix proteins to DNA translocation via nanopores. Recently his exploration has focused on studying mobile division with microorganisms on chip, whilst his top fascination is during the course of recognizing artificial cells.
Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative trend
In 1993, being a youthful and keen affiliate professor at Delft College of Engineering, I'd ceesdekker.net in the beginning focused the investigation endeavours of my team on measuring the electrical conductance of a single conducting-polymer molecule. Inside of two yrs, we experienced created a device during which one wire of the phthalocyaninepolysiloxane polymer was related between two closely spaced metal nanoelectrodes.
Resolving the stage dimension in condensin-driven DNA loop extrusion identifies ATP binding as the step-generating process
Case in point (4) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in gray, the rim in the pore is highlighted in red, and a 3D rendering of your motion from the DNA rod is exhibited.
Afterwards we spoke once again briefly mainly because Dekker felt that our dialogue of his faith rapidly grew to become purely philosophical, While What's more, it concretely allows him in his work.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
 Last but not least, I'll briefly sketch several of our Thoughts to explore the developing of synthetic cells, particularly our very first methods to determine artificial cell division.